Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918165 | 0.84 | KDM4E (0.43) | ALDH1A1HSD17B10GAAMETAP2KDM4E | |
| SCHEMBL6918392 | 0.81 | MAP4K4 (0.47) | MAP4K4CSF1RFGFR1PDGFRALTK | |
| SCHEMBL6820273 | 0.79 | KDR (0.67) | GAAMAP4K4CSF1RFGFR1PDGFRA | |
| SCHEMBL6920075 | 0.79 | BTK (0.48) | ALDH1A1MAP4K4CSF1RFGFR1PDGFRA | |
| SCHEMBL28369687 | 0.75 | CHEK1 (0.55) | ALDH1A1HSD17B10GAAMAP4K4CSF1R | |
| SCHEMBL6661467 | 0.71 | CHEK1 (0.46) | GAAMAP4K4CSF1RFGFR1PDGFRA | |
| SCHEMBL6667507 | 0.71 | MAP4K4 (0.48) | ALDH1A1MAP4K4CSF1RFGFR1PDGFRA | |
| SCHEMBL6919881 | 0.71 | KDM4E (0.45) | ALDH1A1HSD17B10KDM4EGABRG2GABRB3 | |
| SCHEMBL16680793 | 0.71 | KDR (0.56) | ALDH1A1HSD17B10GAAMAP4K4CSF1R | |
| SCHEMBL8034985 | 0.68 | ALDH1A1 (0.54) | ALDH1A1HSD17B10GAAMETAP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |