Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661870 | 0.80 | NISCH (0.33) | CHEK1FLT3PLK3FGFR1KDR | |
| SCHEMBL15995778 | 0.78 | CHEK1 (0.60) | CHEK1FLT3PLK3CSF1RFGFR1 | |
| SCHEMBL6820273 | 0.76 | KDR (0.67) | CHEK1FLT3PLK3CSF1RFGFR1 | |
| SCHEMBL6919665 | 0.71 | ALDH1A1 (0.45) | CHEK1FLT3PLK3CSF1RFGFR1 | |
| SCHEMBL6919318 | 0.71 | PDPK1 (0.51) | CHEK1FLT3PLK3PDPK1CYP3A4 | |
| SCHEMBL6918392 | 0.70 | MAP4K4 (0.47) | CSF1RFGFR1KDRAURKBCDK5 | |
| SCHEMBL20297424 | 0.69 | BACE1 (0.41) | CHEK1FLT3PLK3CSF1RFGFR1 | |
| SCHEMBL6920075 | 0.68 | BTK (0.48) | CSF1RFGFR1KDRAURKBCDK5 | |
| SCHEMBL10368900 | 0.66 | CHEK1 (0.64) | CHEK1FLT3PLK3CSF1RFGFR1 | |
| SCHEMBL3654198 | 0.65 | CHEK1 (0.62) | CHEK1FLT3PLK3CSF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016270-A1 | USE OF Itk INHIBITORS FOR THE TREATMENT OF MAST CELL-DRIVEN OR BASOPHIL-DRIVEN DISEASES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |