Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932083 | 0.74 | BACE1 (0.50) | BACE1BACE2KCNH2 | |
| SCHEMBL932175 | 0.73 | BACE1 (0.51) | BACE1BACE2KCNH2 | |
| SCHEMBL932392 | 0.70 | BACE1 (0.65) | BACE1BACE2KCNH2 | |
| SCHEMBL931679 | 0.69 | BACE1 (0.77) | BACE1BACE2KCNH2 | |
| SCHEMBL932089 | 0.68 | BACE1 (0.62) | BACE1BACE2KCNH2 | |
| SCHEMBL932267 | 0.64 | GAA (0.47) | BACE1BACE2KCNH2 | |
| SCHEMBL932204 | 0.61 | BACE1 (0.67) | BACE1BACE2KCNH2 | |
| SCHEMBL932844 | 0.60 | BACE1 (0.50) | BACE1BACE2KCNH2 | |
| SCHEMBL931666 | 0.60 | BACE1 (0.74) | BACE1BACE2KCNH2 | |
| SCHEMBL932012 | 0.60 | BACE1 (0.78) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |