Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681777 | 0.83 | MAPT (0.58) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL2299750 | 0.80 | CDYL2 (0.38) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL7218237 | 0.79 | MAPT (0.74) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL6297845 | 0.77 | MAPT (0.59) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL5805590 | 0.77 | MAPT (0.52) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL5279457 | 0.75 | IDO1 (0.59) | MAPTALDH1A1L3MBTL1GAAIDO1 | |
| SCHEMBL1461839 | 0.75 | MAPT (0.56) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL7946700 | 0.74 | HDAC3 (0.47) | ALDH1A1KMT2AGAAPOLBMAPK1 | |
| SCHEMBL7093706 | 0.74 | MAPT (0.55) | MAPTALDH1A1L3MBTL1TDP1MEN1 | |
| SCHEMBL10594322 | 0.73 | MAPT (0.51) | MAPTALDH1A1L3MBTL1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421866-A1 | 3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121995-A1 | 3,3'-SPIROINDOLINONE DERIVATIVES AND THEIR USE FOR CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | disclosed |