Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619302 | 0.89 | ALDH1A1 (0.62) | MAPTALDH1A1L3MBTL1KDM4ETDP2 | |
| SCHEMBL8971019 | 0.85 | MAPT (1.00) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL7681777 | 0.83 | MAPT (0.58) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL14364502 | 0.82 | ALDH1A1 (0.59) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL11789979 | 0.82 | TDP2 (0.68) | MAPTALDH1A1L3MBTL1KDM4ETDP2 | |
| SCHEMBL28087596 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1L3MBTL1KDM4ETDP2 | |
| SCHEMBL16349772 | 0.81 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL10753453 | 0.81 | MAPT (0.54) | MAPTALDH1A1L3MBTL1KDM4ENLRP3 | |
| SCHEMBL10738796 | 0.81 | ALDH1A1 (0.51) | MAPTALDH1A1L3MBTL1KDM4ETDP2 | |
| SCHEMBL22152022 | 0.80 | TDP2 (0.69) | MAPTALDH1A1L3MBTL1KDM4ETDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014068341-A2 | CHIRAL FLUORINATING REAGENTS | ISIS INNOVATION LIMITED (GB) | 2014-05-08 | — | — | WO | disclosed |
| US-6541503-B2 | Preventing chemotherapy induced alopecia. | SMITHKLINE BEECHAM CORPORATION | 2003-04-01 | — | — | US | disclosed |
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | disclosed |