SCHEMBL6920216

SCHEMBL6920216

Cc1nn(CCO)c(C)c1Br

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APAF1 O14727 1/20 0.50
ALDH1A1 P00352 6/20 0.46
ATM Q13315 1/20 0.45
HTT P42858 5/20 0.43
NPSR1 Q6W5P4 3/20 0.43
AGTR1 P30556 1/20 0.43
GAA P10253 3/20 0.42
LMNA P02545 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C19 P33261 1/20 0.42
HPGD P15428 2/20 0.41
CSNK2A2 P19784 1/20 0.39
CSNK2B P67870 1/20 0.39
CSNK2A1 P68400 1/20 0.39
CSNK2A3 Q8NEV1 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.38
GLS O94925 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1850785 0.88 APAF1 (0.47) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL8660934 0.83 APAF1 (0.53) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL6417827 0.79 ALDH1A1 (0.58) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL12121227 0.78 ALDH1A1 (0.53) APAF1ALDH1A1HTTGAACYP1A2
Hydrochloric Acid SCHEMBL6423223 0.78 ALDH1A1 (0.61) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL13117395 0.77 APAF1 (0.45) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL2943809 0.76 HPGD (0.52) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL1855322 0.76 ALDH1A1 (0.50) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL16441688 0.76 APAF1 (0.44) APAF1ALDH1A1ATMHTTNPSR1
SCHEMBL24746729 0.76 HTT (0.39) APAF1ALDH1A1ATMHTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004011446-A1 INDANE, DIHYDROBENZOFURAN, AND TETRAHYDRONAPHTHALENE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2004-02-05 WO disclosed