Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133518 | 0.88 | USP2 (0.46) | HTTUSP2MAPK1ALDH1A1MAPT | |
| SCHEMBL6133653 | 0.87 | ALDH1A1 (0.54) | TSHRUSP2MAPK1ALDH1A1MAPT | |
| SCHEMBL6133697 | 0.86 | HSD17B10 (0.46) | HTTKDM4EUSP2MAPK1ALDH1A1 | |
| SCHEMBL6134015 | 0.84 | KDM4E (0.45) | HTTKDM4ETSHRALDH1A1MAPT | |
| SCHEMBL6828616 | 0.84 | USP2 (0.43) | HTTKDM4EUSP2MAPK1ALDH1A1 | |
| SCHEMBL6133400 | 0.84 | KDM4E (0.48) | HTTKDM4ETSHRALDH1A1MAPT | |
| SCHEMBL6133434 | 0.82 | ALDH1A1 (0.46) | HTTKDM4EMAPK1ALDH1A1MAPT | |
| SCHEMBL6133701 | 0.82 | KDM4E (0.46) | HTTKDM4ETSHRUSP2MAPK1 | |
| SCHEMBL6133255 | 0.80 | HTT (0.47) | HTTKDM4ETSHRUSP2MAPK1 | |
| SCHEMBL6133760 | 0.80 | MAOB (0.40) | HTTALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441732-A2 | THIAZOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039451-A2 | THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-15 | — | — | WO | disclosed |