Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133697 | 0.92 | HSD17B10 (0.46) | USP2MAPK1ALDH1A1CNR1CNR2 | |
| SCHEMBL6133653 | 0.89 | ALDH1A1 (0.54) | USP2MAPK1ALDH1A1CNR1CNR2 | |
| SCHEMBL6828616 | 0.89 | USP2 (0.43) | USP2MAPK1ALDH1A1CNR1CNR2 | |
| SCHEMBL6920286 | 0.88 | HTT (0.43) | USP2MAPK1ALDH1A1CNR1CNR2 | |
| SCHEMBL6133434 | 0.87 | ALDH1A1 (0.46) | MAPK1ALDH1A1CNR1CNR2MAPT | |
| SCHEMBL6133574 | 0.86 | HSD17B10 (0.46) | USP2ALDH1A1SMN1; SMN2ADORA2AHSD17B10 | |
| SCHEMBL6133760 | 0.84 | MAOB (0.40) | ALDH1A1CNR1CNR2SMN1; SMN2ADORA1 | |
| SCHEMBL6133356 | 0.84 | KDM4E (0.51) | ALDH1A1SMN1; SMN2ADORA2AHSD17B10PDE4B | |
| SCHEMBL6133611 | 0.83 | HTT (0.44) | SMN1; SMN2ADORA1ADORA2AHSD17B10PDE4B | |
| SCHEMBL6133966 | 0.81 | HTT (0.52) | USP2MAPK1ALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | USP2 4097/4885MAPK1 3652/4885ALDH1A1 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.