Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010064 | 1.00 | FDPS (0.46) | FDPSTSHRNLRP3PDE4BLMNA | |
| SCHEMBL3003330 | 0.82 | FDPS (0.47) | FDPSTSHRNLRP3PDE4BLMNA | |
| SCHEMBL19222041 | 0.81 | LMNA (0.36) | FDPSTSHRPDE4BLMNAADRB2 | |
| SCHEMBL19222168 | 0.81 | FDPS (0.43) | FDPSTSHRNLRP3ADRB2ADRB1 | |
| SCHEMBL2162547 | 0.79 | — | — | |
| SCHEMBL14653801 | 0.75 | FDPS (0.48) | FDPSTSHRNLRP3LMNAADRB2 | |
| SCHEMBL14478268 | 0.75 | — | — | |
| SCHEMBL18231656 | 0.75 | — | — | |
| SCHEMBL34468064 | 0.75 | — | — | |
| SCHEMBL11189962 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051342-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |