Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919278 | 0.88 | ENPP1 (0.43) | MAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL7129327 | 0.85 | XDH (0.42) | MAPTSMN1; SMN2NOTUMNR1H2NR1H3 | |
| SCHEMBL6920075 | 0.85 | BTK (0.48) | NOTUMNR1H2NR1H3ALDH1A1LMNA | |
| SCHEMBL6662853 | 0.82 | CSF1R (0.50) | MAPTSMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL6918165 | 0.79 | KDM4E (0.43) | MAPTALDH1A1XDHDCUN1D1GAA | |
| SCHEMBL6917745 | 0.77 | IDO1 (0.41) | MAPTSMN1; SMN2ALDH1A1LMNABTK | |
| SCHEMBL6919881 | 0.75 | KDM4E (0.45) | ALDH1A1 | |
| SCHEMBL6918392 | 0.72 | MAP4K4 (0.47) | MAPTBTK | |
| SCHEMBL13538503 | 0.71 | MAPT (0.54) | MAPTSMN1; SMN2NOTUMALDH1A1LMNA | |
| SCHEMBL2662066 | 0.71 | BTK (0.58) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |