Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920865 | 0.85 | SERPINE1 (0.41) | XDHALDH1A1NOTUMNR1H2NR1H3 | |
| SCHEMBL6920075 | 0.85 | BTK (0.48) | XDHALDH1A1NOTUMNR1H2NR1H3 | |
| SCHEMBL6918392 | 0.72 | MAP4K4 (0.47) | BTKMAPTDYRK1ACLK4CYP1A2 | |
| SCHEMBL6919278 | 0.72 | ENPP1 (0.43) | LMNAGAAMAPTSMN1; SMN2HPGD | |
| SCHEMBL2662066 | 0.68 | BTK (0.58) | BTK | |
| SCHEMBL13538503 | 0.68 | MAPT (0.54) | ALDH1A1NOTUMLMNABRD4MAPT | |
| SCHEMBL4713814 | 0.67 | ADORA2A (0.50) | XDHALDH1A1NOTUMNR1H2NR1H3 | |
| SCHEMBL2020140 | 0.67 | ABL1 (0.59) | ALDH1A1LMNABRD4GAATDO2 | |
| SCHEMBL6820273 | 0.65 | KDR (0.67) | LMNAGAACLK4KMT2A | |
| SCHEMBL6662853 | 0.65 | CSF1R (0.50) | ALDH1A1LMNAGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016615-A1 | PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | claimed |