Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968151 | 0.74 | ALDH1A1 (0.40) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL3970342 | 0.72 | KDM4E (0.52) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL3966510 | 0.71 | ALDH1A1 (0.38) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL3924161 | 0.70 | CRHR1 (0.41) | CRHR1LMNAALDH1A1HPGDHSD17B10 | |
| SCHEMBL20528869 | 0.69 | ALDH1A1 (0.42) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL25151362 | 0.69 | ALDH1A1 (0.42) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL3923464 | 0.68 | SMPD3 (0.36) | CRHR1ALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL3959800 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1HPGDHSD17B10SMPD3 | |
| SCHEMBL25151627 | 0.67 | ALDH1A1 (0.40) | LMNACYP1A2MAPK1ALDH1A1HPGD | |
| SCHEMBL25151336 | 0.67 | SMPD3 (0.38) | LMNAALDH1A1HPGDHSD17B10SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051342-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |