Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | MAX | P61244 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921876 | 0.83 | CXCR2 (0.66) | ALDH1A1KMT2AMEN1MAPTCXCR1 | |
| SCHEMBL6824084 | 0.81 | RORC (0.56) | ALDH1A1KMT2AMEN1MAPTCXCR1 | |
| SCHEMBL6920946 | 0.81 | CXCR1 (0.72) | ALDH1A1KMT2AMEN1MYCMAX | |
| SCHEMBL3715203 | 0.81 | CXCR1 (0.72) | ALDH1A1KMT2AMEN1MYCMAX | |
| SCHEMBL6820172 | 0.81 | MEN1 (0.59) | ALDH1A1KMT2AMEN1MAPTKCNMA1 | |
| SCHEMBL7489294 | 0.79 | KMT2A (0.51) | KMT2AMEN1MAPTCXCR1CXCR2 | |
| SCHEMBL5594774 | 0.78 | CXCR2 (0.72) | ALDH1A1KMT2AMEN1MYCMAX | |
| SCHEMBL6823879 | 0.78 | AKR1C3 (0.44) | ALDH1A1KMT2AMEN1MAPTCXCR1 | |
| SCHEMBL7539557 | 0.76 | KMT2A (0.55) | ALDH1A1KMT2AMEN1MAPTCXCR1 | |
| SCHEMBL6920112 | 0.75 | MEN1 (0.46) | ALDH1A1KMT2AMEN1MAPTCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |