Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920978 | 1.00 | KLK7 (0.46) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL6920826 | 0.89 | KDM4E (0.41) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL7989930 | 0.88 | GPR119 (0.45) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL7989927 | 0.88 | GPR119 (0.45) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL25819373 | 0.84 | GPR119 (0.51) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL7496058 | 0.84 | GPR119 (0.51) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL7497146 | 0.84 | GPR119 (0.51) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL29922276 | 0.83 | GPR119 (0.49) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL7302589 | 0.83 | P2RX7 (0.42) | KLK7KLK5GPR119KDM4EPKM | |
| SCHEMBL6448978 | 0.82 | KLK7 (0.43) | KLK7KLK5PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058702-A2 | 4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |