Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GRK2 | P25098 | 2/20 | 0.47 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053657 | 0.86 | STAT3 (0.61) | STAT3ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6921467 | 0.81 | STAT3 (0.70) | STAT3ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL12059006 | 0.76 | RAB9A (0.54) | ALDH1A1HPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6921950 | 0.74 | MAPK14 (0.47) | ALDH1A1GRK2GRK1GAAHDAC3 | |
| SCHEMBL6922249 | 0.73 | MAPT (0.46) | ALDH1A1SMN1; SMN2RAB9ANPC1GRK2 | |
| SCHEMBL6921393 | 0.70 | KDM4E (0.56) | ALDH1A1KDM4EHPGDRAB9AHSD17B10 | |
| SCHEMBL5312149 | 0.70 | HDAC3 (0.61) | KDM4EHPGDSMN1; SMN2GRK2GRK1 | |
| SCHEMBL14478795 | 0.69 | PDE5A (0.65) | HPGDSMN1; SMN2GRK2GRK1PKM | |
| SCHEMBL6277525 | 0.69 | MCHR1 (0.53) | ALDH1A1GRK2GRK1HDAC3HDAC4 | |
| SCHEMBL6922028 | 0.68 | SLC2A1 (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | GRM5, GRM2, GRM1 | STAT3 1243/4885ALDH1A1 1721/4885KDM4E 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.