SCHEMBL6922440

SCHEMBL6922440

N#Cc1ccc(-c2cncc(Cl)c2CO)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 13/20 0.47
CYP11B1 P15538 10/20 0.47
SLC22A12 Q96S37 2/20 0.46
CASP1 P29466 1/20 0.40
CYP19A1 P11511 1/20 0.39
TRPV4 Q9HBA0 1/20 0.38
EIF4E P06730 1/20 0.38
USP7 Q93009 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6920948 0.88 CYP11B2 (0.50) CYP11B2CYP11B1SLC22A12
SCHEMBL14225087 0.78 ALDH1A1 (0.36) CYP11B2CYP11B1USP7
SCHEMBL14225086 0.76 SLC22A12 (0.50) CYP11B2CYP11B1SLC22A12
SCHEMBL1769857 0.74 RPS6KA3 (0.48) SLC22A12USP7
SCHEMBL14152183 0.74 CYP11B2 (0.46) CYP11B2CYP11B1SLC22A12
SCHEMBL14240045 0.72 CYP11B2 (0.48) CYP11B2CYP11B1
SCHEMBL1770160 0.71 CSNK1D (0.43) CYP11B2CYP11B1SLC22A12CASP1
SCHEMBL14240047 0.71 CYP11B2 (0.49) CYP11B2CYP11B1SLC22A12CASP1
SCHEMBL14152211 0.70 CYP11B2 (0.50) CYP11B2CYP11B1SLC22A12
SCHEMBL6921274 0.70 CYP11B2 (0.50) CYP11B2CYP11B1SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2501678-B1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2015-09-23 EP claimed
EP-2501678-B1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2015-09-23 EP disclosed
CN-102712589-A Aryl-pyridine derivatives as aldosterone synthase inhibitors NOVARTIS AG 2012-10-03 CN disclosed
WO-2011061168-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2011-05-26 WO disclosed