Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.66 |
| ▸ | ATP4A | P20648 | 1/20 | 0.53 |
| ▸ | ATP4B | P51164 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10918911 | 0.82 | ATP4A (0.76) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7499341 | 0.80 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL6926551 | 0.75 | CYP3A4 (0.63) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL8803895 | 0.72 | CYP3A4 (0.83) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7216941 | 0.71 | CYP3A4 (0.81) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL4891085 | 0.70 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL4888948 | 0.70 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7984904 | 0.69 | ATP4A (0.73) | CYP3A4CYP2C9CYP1A2CYP2D6ATP4A | |
| SCHEMBL2192969 | 0.69 | ATP4A (1.00) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL11001197 | 0.69 | ATP4A (0.73) | CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042324-B1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | ASTRAZENECA AB (SE) | 2003-02-26 | — | — | EP | claimed |
| US-6518270-B1 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | claimed |
| EP-1042324-A1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | AstraZeneca AB (SE) | 2000-10-11 | — | — | EP | claimed |
| WO-1999028322-A1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | ASTRAZENECA AB (SE) | 1999-06-10 | — | — | WO | claimed |
| EP-1042324-B1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | ASTRAZENECA AB (SE) | 2003-02-26 | — | — | EP | disclosed |
| US-6518270-B1 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof | ASTRAZENECA AB (SE) | 2003-02-11 | — | — | US | disclosed |
| EP-1042324-A1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | AstraZeneca AB (SE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999028322-A1 | HETEROCYCLIC COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | ASTRAZENECA AB (SE) | 1999-06-10 | — | — | WO | disclosed |