Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 4/20 | 0.32 |
| ▸ | CA4 | P22748 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18270044 | 0.81 | ERN1 (0.41) | ERN1PRKDCPTPN1AKR1B1CA2 | |
| SCHEMBL15961260 | 0.81 | PTPN1 (0.48) | ERN1PRKDCPTPN1AKR1B1CA2 | |
| SCHEMBL6828617 | 0.78 | ERN1 (0.34) | ERN1PRKDCPTPN1IMPDH2CA2 | |
| SCHEMBL1637371 | 0.76 | IMPDH2 (0.37) | ERN1PRKDCAKR1B1IMPDH2IGF1R | |
| SCHEMBL11928781 | 0.76 | NPSR1 (0.36) | ERN1PTPN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL25342040 | 0.75 | IGF1R (0.36) | ERN1PRKDCAKR1B1IMPDH2IGF1R | |
| SCHEMBL4943759 | 0.75 | IMPDH2 (0.42) | ERN1AKR1B1IMPDH2IGF1RSRC | |
| SCHEMBL14703277 | 0.75 | ERN1 (0.33) | ERN1PRKDCIGF1RSRCAXL | |
| SCHEMBL8684241 | 0.74 | PTPN1 (0.41) | ERN1PRKDCPTPN1AKR1B1CA2 | |
| SCHEMBL10503320 | 0.74 | ERN1 (0.49) | ERN1PRKDCPTPN1AKR1B1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073612-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-09-02 | — | — | WO | disclosed |