Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9741137 | 0.86 | NPC1 (0.57) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL9588889 | 0.82 | NPC1 (0.70) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL15516309 | 0.82 | NPC1 (0.66) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL2559038 | 0.82 | NPC1 (0.61) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL4291027 | 0.81 | NPC1 (0.64) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL1163050 | 0.81 | NPC1 (0.64) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL8705480 | 0.79 | NPC1 (0.61) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL6978902 | 0.78 | NPC1 (0.60) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL3081379 | 0.77 | RAB9A (0.66) | NPC1RAB9APLAUCASP3POLB | |
| SCHEMBL8894000 | 0.77 | NPC1 (0.58) | NPC1RAB9APLAUCASP3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518260-B1 | (α-aminophosphino) peptide derivatives, method for making same and therapeutic applications thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2003-02-11 | — | — | US | disclosed |
| US-6391866-B1 | ANALGESICS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-05-21 | — | — | US | disclosed |