SCHEMBL7904599

SCHEMBL7904599

c1ccc(-c2ccnc(Nc3ccccn3)c2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 8/20 0.53
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
GFER P55789 1/20 0.52
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
FDPS P14324 1/20 0.50
EGFR P00533 1/20 0.50
KDR P35968 3/20 0.49
CNR1 P21554 1/20 0.46
MAPK8 P45983 2/20 0.45
MAPK9 P45984 2/20 0.45
MAP4K4 O95819 1/20 0.44
ABL1 P00519 1/20 0.44
LCK P06239 1/20 0.44
FYN P06241 1/20 0.44
IGF1R P08069 1/20 0.44
LTK P29376 1/20 0.44
MAP2K2 P36507 1/20 0.44
CLK2 P49760 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6923905 0.89 MAPK10 (0.57) MAPK10MEN1KMT2AGFERMAPK8
SCHEMBL13151491 0.83 MAPK10 (0.62) MAPK10NPC1RAB9AFDPSEGFR
SCHEMBL29391624 0.79 KMT2A (0.76) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL221242 0.79 KMT2A (0.76) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL11133606 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL4243882 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL30947359 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL6175584 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1
SCHEMBL6574416 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1
Bromide SCHEMBL28368455 0.77 KMT2A (0.73) MAPK10MEN1KMT2AGFERNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10876047-B2 Phosphorescent emitting compositions R DISPLAY & LIGHTING LLC (US) 2020-12-29 US disclosed
EP-2391605-B1 SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY KARUS THERAPEUTICS LTD (GB) 2017-11-08 EP disclosed
US-20170174985-A1 PHOSPHORESCENT EMITTING COMPOSITIONS R-Display & Lighting LLC (US) 2017-06-22 US disclosed
US-9340503-B2 Scriptaid isosteres and their use in therapy KARUS THERAPEUTICS, LIMITED (GB) 2016-05-17 US disclosed
US-9340503-B2 Scriptaid isosteres and their use in therapy KARUS THERAPEUTICS, LIMITED (GB) 2016-05-17 US disclosed
US-20140235671-A1 SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2014-08-21 US disclosed
US-20140235671-A1 SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2014-08-21 US disclosed
US-8748458-B2 Scriptaid isosteres and their use in therapy KARUS THERAPEUTICS LIMITED (GB) 2014-06-10 US disclosed
US-8748458-B2 Scriptaid isosteres and their use in therapy KARUS THERAPEUTICS LIMITED (GB) 2014-06-10 US disclosed
US-20110305729-A1 Scriptaid Isosteres and Their Use in Therapy KARUS THERAPEUTICS LIMITED (GB) 2011-12-15 US disclosed
US-20110305729-A1 Scriptaid Isosteres and Their Use in Therapy KARUS THERAPEUTICS LIMITED (GB) 2011-12-15 US disclosed
WO-2010086646-A1 SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY KARUS THERAPEUTICS LIMITED (GB) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235671-A1 SCRIPTAID ISOSTERES AND THEIR USE IN THERAPY QARS1, C1QBP, QTRT1 MAPK10 3799/4885MEN1 3591/4885KMT2A 1846/4885
US-20110305729-A1 Scriptaid Isosteres and Their Use in Therapy QARS1, C1QBP, C1S MAPK10 3699/4885MEN1 3542/4885KMT2A 1856/4885
US-20170174985-A1 PHOSPHORESCENT EMITTING COMPOSITIONS OCIAD2, OCIAD1, ORC3 MAPK10 1921/4885MEN1 2088/4885KMT2A 4169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.