Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 7/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683584 | 0.88 | MEN1 (0.53) | MEN1KMT2AHDAC4SIGMAR1MAPK1 | |
| SCHEMBL1824893 | 0.86 | SIGMAR1 (0.40) | MEN1KMT2AHDAC4SIGMAR1MAPK1 | |
| SCHEMBL2395917 | 0.86 | MAPK1 (0.69) | MEN1KMT2AHDAC4SIGMAR1MAPK1 | |
| SCHEMBL10287534 | 0.84 | SIGMAR1 (0.71) | HDAC4SIGMAR1DRD4NAMPTOPRM1 | |
| SCHEMBL6585625 | 0.84 | DRD4 (0.63) | MEN1KMT2AHDAC4SIGMAR1MAPK1 | |
| SCHEMBL2395932 | 0.84 | DRD4 (0.67) | HDAC4SIGMAR1MAPK1DRD4NAMPT | |
| SCHEMBL6043125 | 0.84 | MEN1 (0.58) | MEN1KMT2AHDAC4MAPK1DRD4 | |
| SCHEMBL2392338 | 0.83 | DRD4 (0.56) | MEN1KMT2AHDAC4SIGMAR1MAPK1 | |
| SCHEMBL6042349 | 0.82 | SIGMAR1 (0.59) | MEN1KMT2AHDAC4SIGMAR1DRD4 | |
| SCHEMBL2395803 | 0.81 | LMNA (0.60) | MEN1KMT2AHDAC4SIGMAR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058727-A1 | SUBSTITUTED 3,5-DIHYDRO-4H-IMIDAZOL-4-ONES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |