Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | IDH2 | P48735 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926267 | 0.89 | MAPT (0.51) | TSHRMAPTTP53IDH2KMT2A | |
| SCHEMBL6924788 | 0.89 | MAPT (0.52) | TSHRMAPTTP53IDH2KMT2A | |
| SCHEMBL6926782 | 0.87 | MAPT (0.66) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL6926930 | 0.81 | TSHR (0.51) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL6926724 | 0.79 | CBFB (0.55) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL6926524 | 0.78 | MAPT (0.68) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL11369834 | 0.77 | TSHR (0.48) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL6927130 | 0.77 | ALDH1A1 (0.53) | MAPTTP53IDH2KMT2AMEN1 | |
| SCHEMBL6927054 | 0.77 | TSHR (0.48) | TSHRMAPTTP53KMT2AMEN1 | |
| SCHEMBL6926929 | 0.77 | METAP2 (0.51) | TSHRMAPTTP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |