Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 8/20 | 0.66 |
| ▸ | DPP4 | P27487 | 8/20 | 0.66 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820118 | 0.86 | DPP4 (0.78) | ANPEPDPP4NR1H2NR1H3FAAH | |
| SCHEMBL29366407 | 0.86 | DPP4 (0.78) | ANPEPDPP4NR1H2NR1H3FAAH | |
| SCHEMBL300362 | 0.83 | DPP4 (0.61) | ANPEPDPP4NR1H2NR1H3MEN1 | |
| SCHEMBL30954668 | 0.81 | ANPEP (0.67) | ANPEPDPP4NR1H2NR1H3FAAH | |
| SCHEMBL17531021 | 0.81 | ANPEP (0.67) | ANPEPDPP4NR1H2NR1H3FAAH | |
| SCHEMBL13171786 | 0.81 | ANPEP (0.71) | ANPEPDPP4NR1H2NR1H3 | |
| SCHEMBL173289 | 0.80 | ANPEP (1.00) | ANPEPDPP4NR1H2NR1H3 | |
| SCHEMBL9812636 | 0.80 | ANPEP (0.69) | ANPEPDPP4NR1H2NR1H3 | |
| SCHEMBL2818285 | 0.80 | ANPEP (1.00) | ANPEPDPP4NR1H2NR1H3POLB | |
| SCHEMBL300361 | 0.79 | DPP4 (0.60) | ANPEPDPP4NR1H2NR1H3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |