Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28787158 | 0.88 | EGFR (0.52) | EGFRPTGS2XDHMAPT | |
| SCHEMBL6667541 | 0.85 | EGLN1 (0.46) | MAP4K4MINK1TNIKEGLN2GSK3B | |
| SCHEMBL6825145 | 0.84 | EGLN2 (0.42) | MAP4K4MINK1TNIKEGLN2PLAU | |
| SCHEMBL4707492 | 0.83 | SLC6A4 (0.48) | EGFRPTGS2XDHALDH1A1MAPT | |
| SCHEMBL16938242 | 0.82 | CA1 (0.50) | EGFRXDHALDH1A1MAPT | |
| SCHEMBL6924636 | 0.81 | SLC2A1 (0.51) | MAP4K4MINK1TNIKEGLN2PLAU | |
| SCHEMBL28270387 | 0.81 | EGFR (0.52) | EGFRPTGS2MAPT | |
| SCHEMBL5937242 | 0.80 | NOTUM (0.47) | GSK3BEGFR | |
| SCHEMBL2428847 | 0.79 | MAPK14 (0.52) | MAP4K4MINK1TNIKEGLN2PLAU | |
| SCHEMBL29976609 | 0.78 | CA1 (0.44) | XDHNAMPTALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004007493-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |