Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925340 | 0.84 | MAP4K4 (0.45) | EGLN2PLAUPOLBRXFP1MRGPRX4 | |
| SCHEMBL6824658 | 0.84 | SLC6A4 (0.45) | L3MBTL1POLBEGFRALDH1A1MAPT | |
| SCHEMBL5937417 | 0.81 | EGFR (0.44) | MRGPRX4EGFR | |
| SCHEMBL6924636 | 0.78 | SLC2A1 (0.51) | EGLN2PLAUPOLBRXFP1KDM1A | |
| SCHEMBL18973312 | 0.77 | RAB9A (0.48) | TDP1RXFP1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL2428847 | 0.76 | MAPK14 (0.52) | EGLN2PLAUPOLBRXFP1KDM1A | |
| SCHEMBL7401479 | 0.74 | CA1 (0.53) | EGLN2PLAUTDP1L3MBTL1POLB | |
| SCHEMBL13063631 | 0.74 | CA1 (0.53) | EGLN2PLAUTDP1L3MBTL1POLB | |
| SCHEMBL2417490 | 0.74 | KDM4E (0.43) | TDP1L3MBTL1POLBEGFRALDH1A1 | |
| SCHEMBL14901975 | 0.74 | ALDH1A1 (0.48) | TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004007493-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |