Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acarbose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY2A known ✓ | P04746 | 9/20 | 0.91 |
| ▸ | MGAM known ✓ | O43451 | 6/20 | 0.91 |
| ▸ | SI | P14410 | 5/20 | 0.91 |
| ▸ | GAA | P10253 | 4/20 | 0.91 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.91 |
| ▸ | CNR1 | P21554 | 1/20 | 0.91 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.91 |
| ▸ | PDE4A | P27815 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.91 |
| ▸ | GLA | P06280 | 1/20 | 0.91 |
| ▸ | TREH | O43280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acarbose SCHEMBL611277 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL14223718 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL681337 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252576 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22651301 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| SCHEMBL14409049 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL4068725 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL9929862 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL22252575 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A | |
| Acarbose SCHEMBL19736300 | 0.95 | AMY2A (1.00) | AMY2AMGAMSIGAAAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573520-B | Therapeutic agent and method for producing the same | 格莱科新诺威逊私人有限公司 | 2024-02-09 | — | — | CN | disclosed |
| US-20160303243-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | GLYCAN BIOSCIENCES LLC (US) | 2016-10-20 | — | — | US | disclosed |
| US-9346845-B2 | Anionic conjugates of glycosylated bacterial metabolite | GLYCAN BIOSCIENCES LLC (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140323422-A1 | Anionic Conjugates of Glycosylated Bacterial Metabolite | Glycosynnovations Pty Ltd (AU) | 2014-10-30 | — | — | US | disclosed |
| US-8791245-B2 | Anionic conjugates of glycosylated bacterial metabolite | Glycan Bioscience LLC (US) | 2014-07-29 | — | — | US | disclosed |
| EP-2421877-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | Glycan Biosciences Pty Ltd (AU) | 2012-02-29 | — | — | EP | disclosed |
| US-20110190233-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | GLYCAN BIOSCIENCES PTY LTD (AU) | 2011-08-04 | — | — | US | disclosed |
| WO-2010037179-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | GLYCAN BIOSCIENCES PTY LTD (AU) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190233-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | GNE, CD44, FUT5 | AMY2A 3179/4885MGAM 63/4885SI 39/4885 |
| US-20160303243-A1 | ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE | GNE, CD44, FUT5 | AMY2A 3179/4885MGAM 63/4885SI 39/4885 |
| US-20140323422-A1 | Anionic Conjugates of Glycosylated Bacterial Metabolite | GNE, CD44, FUT5 | AMY2A 3179/4885MGAM 63/4885SI 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.