Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of 2-Aminoacetophenone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.52 |
| ▸ | CFTR | P13569 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminoacetophenone SCHEMBL309044 | 0.91 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| 2-Aminoacetophenone SCHEMBL29366456 | 0.91 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| 2-Aminoacetophenone SCHEMBL19385986 | 0.89 | ALDH1A1 (0.57) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| 2-Aminoacetophenone SCHEMBL349545 | 0.89 | ALDH1A1 (0.57) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| 2-Aminoacetophenone SCHEMBL22169185 | 0.83 | MAPT (0.53) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| 2-Aminoacetophenone SCHEMBL27637205 | 0.82 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| Ethylenediamine SCHEMBL6690234 | 0.79 | KDM4E (0.54) | ALDH1A1HSD17B10MAPTGAAKDM4E | |
| Kynuramine SCHEMBL30555814 | 0.77 | MAPT (0.50) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| Kynuramine SCHEMBL2801613 | 0.77 | MAPT (0.50) | ALDH1A1HSD17B10CFTRMAPTGAA | |
| SCHEMBL3794838 | 0.75 | BRD4 (0.56) | ALDH1A1HSD17B10CFTRMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472319-A1 | NON-TOXIC CORROSION PROTECTION PIGMENTS BASED ON COBALT | UNIVERSITY OF DAYTON (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003060019-A1 | NON-TOXIC CORROSION PROTECTION PIGMENTS BASED ON COBALT | UNIVERSITY OF DAYTON (US) | 2003-07-24 | — | — | WO | disclosed |