Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.51 |
| ▸ | FEN1 | P39748 | 6/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926065 | 0.77 | MPL (0.50) | MPLFEN1ALOX5APAPPPRKCZ | |
| SCHEMBL20783008 | 0.69 | FFAR4 (0.47) | MPL | |
| SCHEMBL474311 | 0.68 | MPL (1.00) | MPLFEN1ALOX5AP | |
| SCHEMBL28315996 | 0.66 | HSD11B1 (0.50) | MPLFEN1ALOX5APIDO1CYP11B2 | |
| SCHEMBL31064585 | 0.66 | PDE2A (0.39) | IDO1APPPDE2AKIF11 | |
| SCHEMBL28315994 | 0.65 | MPL (0.49) | MPLFEN1ALOX5APIDO1APP | |
| SCHEMBL857195 | 0.65 | IDO1 (0.58) | IDO1APPPDE2A | |
| SCHEMBL29738028 | 0.65 | IDO1 (0.58) | IDO1APPPDE2A | |
| SCHEMBL5861822 | 0.64 | ESR1 (0.43) | MPLFEN1ALOX5APIDO1APP | |
| SCHEMBL1888623 | 0.64 | FEN1 (0.46) | MPLFEN1ALOX5APIDO1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109551-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-09-09 | — | — | WO | disclosed |