Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926134 | 1.00 | KCNH2 (0.54) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL6820090 | 0.90 | KCNH2 (0.51) | KCNH2SCN9ASCN5ACYP1A2MAPK14 | |
| SCHEMBL6820074 | 0.90 | KCNH2 (0.51) | KCNH2SCN9ASCN5ACYP1A2MAPK14 | |
| SCHEMBL8072714 | 0.84 | KCNH2 (0.49) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL6932616 | 0.78 | KCNH2 (0.51) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL6932612 | 0.78 | KCNH2 (0.51) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL4748128 | 0.73 | SCN9A (0.75) | KCNH2SCN9ASCN5AMEN1KMT2A | |
| SCHEMBL7236642 | 0.73 | KMT2A (0.46) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL7236635 | 0.73 | KMT2A (0.46) | KCNH2SCN9ASCN5ARAB9ANPC1 | |
| SCHEMBL8075533 | 0.73 | SCN9A (0.71) | KCNH2SCN9ASCN5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| US-6387899-B1 | ANTISEROTONINE AGENTS; ANTIDEPRESSANTS | ASTRAZENECA AB (SE) | 2002-05-14 | — | — | US | disclosed |
| US-6384225-B1 | 5-PIPERIDINYL- OR PIPERAZINYL-SUBSTITUTED 3,4-DIHYDRO-2H-1-BENZOPYRANS | ASTRAZENECA AB (SE) | 2002-05-07 | — | — | US | disclosed |