Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932612 | 1.00 | KCNH2 (0.51) | KCNH2SCN9ASCN5ADRD2DRD3 | |
| SCHEMBL8064360 | 0.80 | ALDH1A1 (0.38) | ALDH1A1GAALMNAKDM4EHSD17B10 | |
| SCHEMBL6926134 | 0.78 | KCNH2 (0.54) | KCNH2SCN9ASCN5AALDH1A1LMNA | |
| SCHEMBL6926137 | 0.78 | KCNH2 (0.54) | KCNH2SCN9ASCN5AALDH1A1LMNA | |
| SCHEMBL6930424 | 0.76 | ALDH1A1 (0.43) | DRD2DRD3HTR2AALDH1A1LMNA | |
| SCHEMBL6930432 | 0.76 | ALDH1A1 (0.43) | DRD2DRD3HTR2AALDH1A1LMNA | |
| SCHEMBL8072714 | 0.75 | KCNH2 (0.49) | KCNH2SCN9ASCN5ADRD2ALDH1A1 | |
| SCHEMBL6820090 | 0.75 | KCNH2 (0.51) | KCNH2SCN9ASCN5AHTR2AWDR5 | |
| SCHEMBL6820074 | 0.75 | KCNH2 (0.51) | KCNH2SCN9ASCN5AHTR2AWDR5 | |
| SCHEMBL7022204 | 0.74 | MTNR1A (0.60) | KCNH2SCN9ASCN5ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025096-B1 | SUBSTITUTED CHROMAN DERIVATIVES | ASTRAZENECA AB (SE) | 2003-11-26 | — | — | EP | disclosed |
| US-6387899-B1 | ANTISEROTONINE AGENTS; ANTIDEPRESSANTS | ASTRAZENECA AB (SE) | 2002-05-14 | — | — | US | disclosed |
| US-6384225-B1 | 5-PIPERIDINYL- OR PIPERAZINYL-SUBSTITUTED 3,4-DIHYDRO-2H-1-BENZOPYRANS | ASTRAZENECA AB (SE) | 2002-05-07 | — | — | US | disclosed |