Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926263 | 1.00 | PIM1 (0.67) | PIM1PIM2HDAC1HDAC8AKR1B1 | |
| SCHEMBL6927012 | 0.86 | PIM1 (0.58) | PIM1PIM2AKR1B1HPGDMAPT | |
| SCHEMBL6926478 | 0.86 | AKR1B1 (0.64) | PIM1PIM2HDAC1AKR1B1HPGD | |
| SCHEMBL6926481 | 0.86 | AKR1B1 (0.64) | PIM1PIM2HDAC1AKR1B1HPGD | |
| SCHEMBL6927788 | 0.86 | AKR1B1 (0.58) | PIM1PIM2AKR1B1HPGDNPC1 | |
| SCHEMBL6928727 | 0.86 | PIM1 (0.58) | PIM1PIM2HDAC8AKR1B1HPGD | |
| SCHEMBL6928730 | 0.86 | PIM1 (0.58) | PIM1PIM2HDAC8AKR1B1HPGD | |
| SCHEMBL6927790 | 0.86 | AKR1B1 (0.58) | PIM1PIM2AKR1B1HPGDNPC1 | |
| SCHEMBL6927009 | 0.86 | PIM1 (0.58) | PIM1PIM2AKR1B1HPGDMAPT | |
| SCHEMBL6928982 | 0.86 | HPGD (0.68) | PIM1PIM2AKR1B1HPGDNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |