Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11372467 | 0.91 | MAPT (0.52) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6925861 | 0.87 | GLO1 (0.47) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6925864 | 0.83 | MEN1 (0.50) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6924681 | 0.83 | MEN1 (0.50) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6925704 | 0.82 | MEN1 (0.49) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6915094 | 0.82 | EGLN1 (0.37) | KMT2AALDH1A1KDM4EGRM4 | |
| SCHEMBL6926045 | 0.80 | MAPT (0.67) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6925491 | 0.79 | GRM4 (0.51) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6925468 | 0.79 | CBFB (0.53) | MEN1KMT2ATSHRMAPTLMNA | |
| SCHEMBL6924792 | 0.78 | METAP2 (0.52) | MEN1KMT2ATSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |