Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RGS4 | P49798 | 1/20 | 0.40 |
| ▸ | RGS8 | P57771 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921048 | 0.91 | HDAC1 (0.43) | MAPTCYP3A4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6924327 | 0.88 | SRC (0.51) | MAPTPLA2G2ACYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL6923683 | 0.86 | KDM4E (0.44) | MAPTPLA2G2AALDH1A1KDM4EMAPK10 | |
| SCHEMBL6923669 | 0.84 | SRC (0.50) | MAPTPLA2G2AALDH1A1KDM4EHSD17B10 | |
| Pyridine SCHEMBL7506032 | 0.81 | SRC (0.44) | MAPTPLA2G2ACYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL5797962 | 0.80 | PTGER4 (0.50) | MAPTPLA2G2ACYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL6924605 | 0.78 | MEN1 (0.43) | MAPTPLA2G2AALDH1A1TSHRNPSR1 | |
| SCHEMBL6921052 | 0.76 | MEN1 (0.43) | MAPTPLA2G2AALDH1A1TSHRTDP1 | |
| SCHEMBL7723992 | 0.76 | SRC (0.53) | MAPTPLA2G2AALDH1A1KDM4ENPSR1 | |
| SCHEMBL7505287 | 0.76 | ESR1 (0.44) | MAPTPLA2G2AKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1169789-C | Aminoalkoxy carbazoles for the treatment of CNS diseases | 法玛西雅厄普约翰美国公司 | 2004-10-06 | — | — | CN | disclosed |
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| CN-1372547-A | Aminoalkoxy carbazoles for the treatment of CNS diseases | UPJOHN CO (US) | 2002-10-02 | — | — | CN | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |