Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921048 | 0.90 | HDAC1 (0.43) | KDM4EKMT2AMEN1HTTLMNA | |
| SCHEMBL6923659 | 0.88 | KMT2A (0.51) | KDM4EP2RX4KMT2AMEN1HTT | |
| SCHEMBL6926577 | 0.86 | MAPT (0.43) | KDM4EKMT2AMEN1LMNAMAPT | |
| SCHEMBL6923669 | 0.83 | SRC (0.50) | KDM4EP2RX4KMT2AMEN1HTT | |
| SCHEMBL6926616 | 0.79 | LMNA (0.44) | KMT2AMEN1LMNAMAPTPLA2G2A | |
| SCHEMBL2156852 | 0.78 | LMNA (0.48) | KDM4EKMT2AMEN1HTTLMNA | |
| SCHEMBL6924126 | 0.77 | ESR1 (0.43) | KDM4EP2RX4KMT2AMEN1LMNA | |
| SCHEMBL7505287 | 0.77 | ESR1 (0.44) | KDM4EKMT2AMEN1MAPTPKM | |
| SCHEMBL6921052 | 0.75 | MEN1 (0.43) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL7723992 | 0.75 | SRC (0.53) | KDM4EP2RX4KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1169789-C | Aminoalkoxy carbazoles for the treatment of CNS diseases | 法玛西雅厄普约翰美国公司 | 2004-10-06 | — | — | CN | disclosed |
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| CN-1372547-A | Aminoalkoxy carbazoles for the treatment of CNS diseases | UPJOHN CO (US) | 2002-10-02 | — | — | CN | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |