Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830491 | 0.93 | GRM5 (0.53) | GRM5MAPTGFERNPSR1CSF1R | |
| SCHEMBL6927362 | 0.89 | GRM5 (0.78) | GRM5MAPTGFERNPSR1ALDH1A1 | |
| SCHEMBL12830505 | 0.88 | GRM5 (0.49) | GRM5MAPTGFERNPSR1CSF1R | |
| SCHEMBL6927293 | 0.86 | GRM5 (0.77) | GRM5MAPTGFERCSF1RALDH1A1 | |
| SCHEMBL12416422 | 0.85 | GRM5 (0.67) | GRM5MAPTGFERNPSR1CSF1R | |
| SCHEMBL12416837 | 0.85 | GRM5 (0.82) | GRM5MAPTGFERNPSR1TSHR | |
| SCHEMBL12830294 | 0.83 | GRM5 (0.66) | GRM5MAPTGFERCSF1RALDH1A1 | |
| SCHEMBL12411969 | 0.81 | CSF1R (0.60) | GRM5MAPTGFERNPSR1CSF1R | |
| SCHEMBL12412763 | 0.81 | GRM5 (0.69) | GRM5MAPTGFERNPSR1CSF1R | |
| SCHEMBL12830487 | 0.81 | GRM5 (0.65) | GRM5MAPTGFERCSF1RTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035174-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |