Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966748 | 0.92 | ALDH1A1 (0.60) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL7178613 | 0.90 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL3959791 | 0.81 | MAPT (0.53) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL7067632 | 0.81 | HPGD (0.61) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL26914710 | 0.81 | MAPT (0.58) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL19700169 | 0.80 | MAPT (0.56) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL102602 | 0.79 | MAPT (0.77) | ALDH1A1MAPTL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL190550 | 0.78 | TDP1 (0.72) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| Aniline SCHEMBL22169175 | 0.77 | TDP1 (0.60) | ALDH1A1L3MBTL1MEN1KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL9438398 | 0.77 | TDP1 (0.69) | ALDH1A1MAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363876-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Abbott Laboratories (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002064550-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2002-08-22 | — | — | WO | disclosed |