Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963525 | 0.95 | HPGD (0.67) | HPGDTDP1ALDH1A1KMT2AATM | |
| SCHEMBL3967775 | 0.88 | KMT2A (0.64) | HPGDTDP1ALDH1A1KMT2AATM | |
| SCHEMBL6927256 | 0.81 | ALDH1A1 (0.53) | TDP1ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL7178613 | 0.77 | MAPT (0.47) | HPGDALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7067634 | 0.76 | HPGD (0.54) | HPGDTDP1ALDH1A1KMT2AATM | |
| SCHEMBL3966748 | 0.73 | ALDH1A1 (0.60) | TDP1ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL15306503 | 0.71 | RAB9A (0.69) | HPGDTDP1ALDH1A1KMT2AATM | |
| SCHEMBL190550 | 0.71 | TDP1 (0.72) | TDP1ALDH1A1KMT2ANPC1MAPT | |
| SCHEMBL6933847 | 0.69 | KMT2A (0.47) | HPGDALDH1A1KMT2AATMMEN1 | |
| Hydrochloric Acid SCHEMBL9438398 | 0.69 | TDP1 (0.69) | TDP1ALDH1A1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363876-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | Abbott Laboratories (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002064550-A1 | GLUCOCORTICOID RECEPTOR MODULATORS | ABBOTT LABORATORIES (US) | 2002-08-22 | — | — | WO | disclosed |