Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSD | A5PKW4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 3/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927645 | 1.00 | PSD (0.54) | PSDLMNARAB9AHTTMAPT | |
| SCHEMBL6927082 | 0.91 | NAMPT (0.51) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6927087 | 0.91 | NAMPT (0.51) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6929936 | 0.89 | KMT2A (0.51) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6929933 | 0.89 | KMT2A (0.51) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6926921 | 0.89 | PIM1 (0.54) | LMNARAB9ASMN1; SMN2HDAC4HDAC8 | |
| SCHEMBL6926923 | 0.89 | PIM1 (0.54) | LMNARAB9ASMN1; SMN2HDAC4HDAC8 | |
| SCHEMBL6927181 | 0.89 | MEN1 (0.52) | LMNAHTTMAPTSMN1; SMN2HDAC4 | |
| SCHEMBL6927180 | 0.89 | MEN1 (0.52) | LMNAHTTMAPTSMN1; SMN2HDAC4 | |
| SCHEMBL6925746 | 0.84 | PIM1 (0.69) | LMNARAB9AMAPTALDH1A1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |