SCHEMBL6927664

SCHEMBL6927664

CCc1ccc(-c2ccc(C(=O)Nc3ccccc3OCCN(CC)CC)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 7/20 0.61
GAA P10253 2/20 0.55
ALDH1A1 P00352 3/20 0.48
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
POLB P06746 2/20 0.46
CACNA1H O95180 1/20 0.46
CACNA1B Q00975 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
KDM4E B2RXH2 1/20 0.46
LMNA P02545 1/20 0.46
EBP Q15125 1/20 0.45
SIGMAR1 Q99720 1/20 0.45
TSHR P16473 1/20 0.45
HRH3 Q9Y5N1 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6898504 0.88 GAA (0.56) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL3500701 0.87 GAA (0.60) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL6927883 0.87 MCHR1 (0.58) MCHR1GAAALDH1A1POLB
SCHEMBL6925417 0.85 GAA (0.58) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL6926348 0.84 GAA (0.57) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL6927791 0.83 GAA (0.59) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL7056986 0.83 CACNA1H (0.63) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL6929529 0.80 MCHR1 (0.65) MCHR1GAAALDH1A1CACNA1HCACNA1B
SCHEMBL6898486 0.80 GAA (0.58) MCHR1GAAALDH1A1NPC1RAB9A
SCHEMBL6921824 0.80 MCHR1 (0.81) MCHR1ALDH1A1NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6515027-B1 Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 SMITHKLINE BEECHAM CORP. 2003-02-04 US claimed
JP-2002511879-A 2002-04-16 JP claimed
EP-1001766-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2001-04-04 EP claimed
EP-1001766-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-05-24 EP claimed
WO-1999001127-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-01-14 WO claimed
EP-4143235-A1 METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION IncellDx, Inc. (US) 2023-03-08 EP disclosed
WO-2021222069-A1 METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION INCELLDX, INC. (US) 2021-11-04 WO disclosed
US-6515027-B1 Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 SMITHKLINE BEECHAM CORP. 2003-02-04 US disclosed