Tetrahydrofuran

Tetrahydrofuran

SCHEMBL6927933

C1CCOC1.CC(C)=O.CO

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
SMN1; SMN2 Q16637 3/20 0.42
LMNA P02545 1/20 0.40
MEN1 O00255 1/20 0.35
TP53 P04637 1/20 0.35
KMT2A Q03164 1/20 0.35
PKM P14618 1/20 0.33
GAA P10253 1/20 0.32
TSHR P16473 2/20 0.31
TTR P02766 1/20 0.31
GLA P06280 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA9 Q16790 1/20 0.31
PIK3CD O00329 1/20 0.30
KDM4E B2RXH2 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL18917647 0.97 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL165529 0.97
Acetone SCHEMBL8877074 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL11690381 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Acetone SCHEMBL2230779 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL10806048 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Dioxane SCHEMBL10806051 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL28186251 0.93 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL3874046 0.90 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2LMNAMEN1TP53
Tetrahydrofuran SCHEMBL1686095 0.88 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2MEN1TP53KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200068916-A1 FLAVOR OIL-AND-FAT MITSUBISHI CORPORATION LIFE SCIENCES LIMITED (JP) 2020-03-05 US disclosed
US-9885005-B2 Phospholipid alpha-linolenic acid composition KOHJIN Life Sciences Co., Ltd. (JP) 2018-02-06 US disclosed
US-20170081610-A1 PHOSPHOLIPID A-LINOLENIC ACID COMPOSITION KOHJIN Life Sciences Co., Ltd. (JP) 2017-03-23 US disclosed
EP-1204671-B1 FLUOROGENIC COMPOUNDS AND USES THEREFOR 3M INNOVATIVE PROPERTIES CO (US) 2003-12-03 EP disclosed
US-6566508-B2 Compound for use in the accurate detection of food parasites 3M INNOVATIVE PROPERTIES COMPANY 2003-05-20 US disclosed
US-20020147317-A1 Fluorogenic compounds and uses therefor 3M INNOVATIVE PROPETIES COMPANY 2002-10-10 US disclosed
EP-1204671-A1 FLUOROGENIC COMPOUNDS AND USES THEREFOR 3M Innovative Properties Company (US) 2002-05-15 EP disclosed
US-6372895-B1 USEFUL IN ASSAYING FOR BIOLOGICAL ACTIVITY 3M INNOVATIVE PROPERTIES COMPANY 2002-04-16 US disclosed
WO-2001010881-A1 FLUOROGENIC COMPOUNDS AND USES THEREFOR 3M INNOVATIVE PROPERTIES COMPANY (US) 2001-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147317-A1 Fluorogenic compounds and uses therefor NOTUM, WEE1, CPSF7 ALDH1A1 762/4885SMN1; SMN2 4730/4885LMNA 3330/4885
US-20170081610-A1 PHOSPHOLIPID A-LINOLENIC ACID COMPOSITION PHOSPHO1, PLD1, PLCG1 ALDH1A1 4177/4885SMN1; SMN2 3880/4885LMNA 370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.