Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.68 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.58 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.58 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.58 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254150 | 0.83 | MEN1 (0.80) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL16316028 | 0.83 | NPC1 (0.59) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL6594189 | 0.82 | NPC1 (0.61) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL2982452 | 0.82 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL6238272 | 0.82 | NPC1 (0.61) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL3131474 | 0.81 | KDM4E (0.53) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3143179 | 0.81 | KCNQ3 (0.58) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL22946413 | 0.81 | HSD11B1 (0.49) | MEN1KMT2ARAB9AMAPTMAPK1 | |
| SCHEMBL3089807 | 0.81 | MEN1 (0.75) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL4254970 | 0.81 | RAB9A (0.75) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| CN-1321153-A | telomerase inhibitors and methods of use thereof | GERON CORP (US) | 2001-11-07 | — | — | CN | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |