Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | NAT1 | P18440 | 1/20 | 0.53 |
| ▸ | MAX | P61244 | 1/20 | 0.53 |
| ▸ | ATIC | P31939 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928484 | 1.00 | PIM1 (0.67) | PIM1PIM2CES1MYCNAT1 | |
| SCHEMBL6927012 | 0.93 | PIM1 (0.58) | PIM1PIM2CES1MYCNAT1 | |
| SCHEMBL6927009 | 0.93 | PIM1 (0.58) | PIM1PIM2CES1MYCNAT1 | |
| SCHEMBL6928923 | 0.87 | PIM1 (0.67) | PIM1PIM2CA12CA1CA2 | |
| SCHEMBL6928927 | 0.87 | PIM1 (0.67) | PIM1PIM2CA12CA1CA2 | |
| SCHEMBL6925745 | 0.84 | PIM1 (0.69) | PIM1PIM2MGAMCA12CA1 | |
| SCHEMBL6929776 | 0.84 | PIM1 (0.69) | PIM1PIM2CA2CA9PIP4K2A | |
| SCHEMBL6929777 | 0.84 | PIM1 (0.69) | PIM1PIM2CA2CA9PIP4K2A | |
| SCHEMBL6925746 | 0.84 | PIM1 (0.69) | PIM1PIM2MGAMCA12CA1 | |
| SCHEMBL6927181 | 0.83 | MEN1 (0.52) | PIM1PIM2HTTAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |