Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.69 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.69 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929777 | 1.00 | PIM1 (0.69) | PIM1PIM2CISD1TTRPTPN1 | |
| SCHEMBL6928481 | 0.84 | PIM1 (0.67) | PIM1PIM2MAOAGSK3BCA2 | |
| SCHEMBL6928927 | 0.84 | PIM1 (0.67) | PIM1PIM2PTPN1MAOACA2 | |
| SCHEMBL6928484 | 0.84 | PIM1 (0.67) | PIM1PIM2MAOAGSK3BCA2 | |
| SCHEMBL6928923 | 0.84 | PIM1 (0.67) | PIM1PIM2PTPN1MAOACA2 | |
| SCHEMBL2544050 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1TTRPTPN1 | |
| SCHEMBL2544047 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1TTRPTPN1 | |
| SCHEMBL2544398 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1TTRPTPN1 | |
| SCHEMBL6926263 | 0.82 | PIM1 (0.67) | PIM1PIM2DRD3KCNH2NR1H4 | |
| SCHEMBL6926265 | 0.82 | PIM1 (0.67) | PIM1PIM2DRD3KCNH2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |