Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.52 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928927 | 1.00 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AALDH1A1 | |
| SCHEMBL6928730 | 0.93 | PIM1 (0.58) | PIM1PIM2HPGDKMT2AALDH1A1 | |
| SCHEMBL6928727 | 0.93 | PIM1 (0.58) | PIM1PIM2HPGDKMT2AALDH1A1 | |
| SCHEMBL6928484 | 0.87 | PIM1 (0.67) | PIM1PIM2HPGDHTTPIP4K2A | |
| SCHEMBL6928481 | 0.87 | PIM1 (0.67) | PIM1PIM2HPGDHTTPIP4K2A | |
| SCHEMBL6925746 | 0.86 | PIM1 (0.69) | PIM1PIM2HPGDKMT2AALDH1A1 | |
| SCHEMBL6925745 | 0.86 | PIM1 (0.69) | PIM1PIM2HPGDKMT2AALDH1A1 | |
| SCHEMBL6929777 | 0.84 | PIM1 (0.69) | PIM1PIM2PIP4K2APIP4K2BMAOA | |
| SCHEMBL6929776 | 0.84 | PIM1 (0.69) | PIM1PIM2PIP4K2APIP4K2BMAOA | |
| SCHEMBL6926481 | 0.83 | AKR1B1 (0.64) | PIM1PIM2HPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |