Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | TACR1 | P25103 | 14/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924700 | 0.90 | KMT2A (1.00) | MEN1LMNAKMT2ATACR1ALDH1A1 | |
| SCHEMBL6925991 | 0.81 | TACR1 (0.78) | LMNATACR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6928393 | 0.79 | TACR1 (0.92) | TACR1 | |
| SCHEMBL7282092 | 0.78 | MEN1 (0.59) | MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL6928161 | 0.78 | TACR1 (1.00) | TACR1 | |
| SCHEMBL6926601 | 0.77 | TACR1 (1.00) | TACR1 | |
| SCHEMBL6923208 | 0.77 | TACR1 (1.00) | TACR1 | |
| SCHEMBL6925884 | 0.76 | TACR1 (1.00) | TACR1 | |
| SCHEMBL6591199 | 0.76 | HTR1A (0.71) | — | |
| SCHEMBL6925888 | 0.76 | TACR1 (1.00) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518273-B1 | 2-aryl indole derivative as antagonists of tachykinins | MERCK SHARP & DOHME LTD. | 2003-02-11 | — | — | US | disclosed |
| WO-2000051984-A1 | 2-ARYL INDOLE DERIVATIVES AS ANTAGONISTS OF TACHYKININS | MERCK SHARP & DOHME LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |