Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TACR1 | P25103 | 6/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928580 | 0.90 | MEN1 (0.82) | KMT2ALMNAMEN1ALDH1A1TACR1 | |
| SCHEMBL766304 | 0.83 | KMT2A (0.71) | KMT2ALMNAMEN1ALDH1A1GLA | |
| SCHEMBL27715387 | 0.82 | MEN1 (0.69) | KMT2ALMNAMEN1MAPT | |
| SCHEMBL11825700 | 0.81 | KMT2A (0.85) | KMT2ALMNAMEN1ALDH1A1GLA | |
| SCHEMBL11829657 | 0.80 | TACR1 (0.73) | KMT2ALMNAMEN1TACR1 | |
| SCHEMBL9215143 | 0.80 | KMT2A (0.66) | KMT2ALMNAMEN1ALDH1A1GLA | |
| SCHEMBL11820831 | 0.80 | HTR1A (0.79) | KMT2ALMNAMEN1 | |
| SCHEMBL6929131 | 0.80 | TACR1 (0.72) | KMT2ALMNAMEN1TACR1 | |
| SCHEMBL2263678 | 0.79 | KMT2A (0.97) | KMT2ALMNAMEN1ALDH1A1GLA | |
| SCHEMBL9650859 | 0.79 | KMT2A (0.66) | KMT2ALMNAMEN1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518273-B1 | 2-aryl indole derivative as antagonists of tachykinins | MERCK SHARP & DOHME LTD. | 2003-02-11 | — | — | US | disclosed |
| WO-2000051984-A1 | 2-ARYL INDOLE DERIVATIVES AS ANTAGONISTS OF TACHYKININS | MERCK SHARP & DOHME LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |