Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.43 |
| ▸ | RARA | P10276 | 3/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 3/20 | 0.41 |
| ▸ | RARG | P13631 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473810 | 0.88 | TTR (0.42) | RXRACYP26A1RARARARBRARG | |
| SCHEMBL6473808 | 0.88 | TTR (0.42) | RXRACYP26A1RARARARBRARG | |
| SCHEMBL6878025 | 0.84 | RXRA (0.62) | RXRACYP26A1PTPN11CYP26B1CYP3A4 | |
| SCHEMBL6821890 | 0.82 | RARA (0.60) | RXRACYP26A1CYP26B1CYP3A4RARA | |
| SCHEMBL6821889 | 0.82 | RARA (0.60) | RXRACYP26A1CYP26B1CYP3A4RARA | |
| SCHEMBL6472625 | 0.81 | CYP26A1 (0.42) | RXRACYP26A1PTPN11CYP26B1CYP3A4 | |
| SCHEMBL6472753 | 0.81 | KDM4E (0.52) | RXRACYP26A1PTPN11CYP26B1CYP3A4 | |
| SCHEMBL6472750 | 0.81 | KDM4E (0.52) | RXRACYP26A1PTPN11CYP26B1CYP3A4 | |
| SCHEMBL6472627 | 0.81 | CYP26A1 (0.42) | RXRACYP26A1PTPN11CYP26B1CYP3A4 | |
| SCHEMBL6874738 | 0.81 | RXRA (0.67) | RXRACYP26A1PTPN11CYP26B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515021-B1 | Bicyclic aromatic compounds | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2003-02-04 | — | — | US | claimed |
| US-6147255-A | TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL COMPLAINTS ASSOCIATED WITH KERATINIZATION DISORDER WHICH HAS EFFECT ON DIFFERENTIATION AND ON PROLIFERATION | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-11-14 | — | — | US | claimed |
| EP-0947496-B1 | Bicyclic aromatic compounds and their use in human and veterinary medicine as well as in cosmetology | GALDERMA RES & DEV (FR) | 2002-10-09 | — | — | EP | disclosed |
| EP-0947496-A1 | Bicyclic aromatic compounds and their use in human and veterinary medicine as well as in cosmetology | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | disclosed |