Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | SELE | P16581 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928587 | 0.81 | CYP2A6 (0.47) | ALDH1A1CYP2A6MAPTNPSR1MEN1 | |
| SCHEMBL6928719 | 0.77 | MCL1 (0.46) | ALDH1A1CYP2A6MAPTNPSR1MEN1 | |
| SCHEMBL6927314 | 0.77 | CYP2A6 (0.43) | ALDH1A1CYP2A6PDE7AMAPTNPSR1 | |
| SCHEMBL6735568 | 0.77 | CYP2A6 (0.73) | ALDH1A1CYP2A6MAPTNPSR1MEN1 | |
| SCHEMBL5661855 | 0.76 | MAPT (0.72) | ALDH1A1PDE7AMAPTNPSR1MEN1 | |
| SCHEMBL1575377 | 0.75 | ALDH1A1 (0.57) | ALDH1A1CYP2A6TDP1HPGDICAM1 | |
| SCHEMBL6200993 | 0.75 | CYP2A6 (0.62) | ALDH1A1CYP2A6ICAM1ITGALITGB2 | |
| SCHEMBL6852277 | 0.75 | PDE7A (0.79) | ALDH1A1PDE7AMAPTNPSR1MEN1 | |
| SCHEMBL6924085 | 0.74 | ERN1 (0.43) | ALDH1A1PDE7AMAPTNPSR1MEN1 | |
| SCHEMBL8678351 | 0.72 | ALDH1A1 (0.51) | ALDH1A1PDE7AMAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |