Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928947 | 1.00 | IGF1R (0.64) | IGF1RPTPN1PPARGHDAC4HDAC8 | |
| SCHEMBL6928856 | 0.85 | AKR1B1 (0.60) | IGF1RHDAC4HDAC8GSK3BAKR1B1 | |
| SCHEMBL6928853 | 0.85 | AKR1B1 (0.60) | IGF1RHDAC4HDAC8GSK3BAKR1B1 | |
| SCHEMBL13846818 | 0.79 | IGF1R (1.00) | IGF1RGSK3BCASP3MEN1MAPT | |
| SCHEMBL1250596 | 0.79 | IGF1R (1.00) | IGF1RGSK3BCASP3MEN1MAPT | |
| SCHEMBL1250598 | 0.79 | IGF1R (1.00) | IGF1RGSK3BCASP3MEN1MAPT | |
| SCHEMBL6929933 | 0.79 | KMT2A (0.51) | PTPN1HDAC4HDAC8MEN1MAPT | |
| SCHEMBL6929936 | 0.79 | KMT2A (0.51) | PTPN1HDAC4HDAC8MEN1MAPT | |
| SCHEMBL6927082 | 0.78 | NAMPT (0.51) | PTPN1PPARGHDAC4HDAC8MEN1 | |
| SCHEMBL6927181 | 0.78 | MEN1 (0.52) | PTPN1HDAC4MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |