Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | SELE | P16581 | 2/20 | 0.41 |
| ▸ | RHEB | Q15382 | 6/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923178 | 0.83 | USP7 (0.37) | MEN1KMT2AICAM1SELERHEB | |
| SCHEMBL6930093 | 0.77 | USP7 (0.39) | MEN1KMT2AUSP7PADI4MAPT | |
| SCHEMBL6922597 | 0.71 | MAOA (0.40) | MEN1KMT2ARHEBUSP7PADI4 | |
| SCHEMBL6489008 | 0.71 | MAPT (0.39) | MEN1KMT2AICAM1SELEUSP7 | |
| SCHEMBL6923956 | 0.70 | USP7 (0.37) | MEN1KMT2AICAM1SELERHEB | |
| SCHEMBL17398498 | 0.69 | RHEB (0.41) | MEN1KMT2AICAM1SELERHEB | |
| SCHEMBL20535763 | 0.68 | MEN1 (0.61) | MEN1KMT2ARHEBMAPTNPSR1 | |
| SCHEMBL6926855 | 0.67 | USP7 (0.46) | MEN1KMT2AICAM1SELERHEB | |
| SCHEMBL17398433 | 0.67 | SLC6A2 (0.42) | MEN1KMT2AICAM1SELERHEB | |
| SCHEMBL5661469 | 0.67 | FBP1 (0.37) | MEN1KMT2ARHEBUSP7PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |